The unadjusted hazard ratios were 1.37 for death, 1.27 for just about any outcome event, and 1.29 for distant disease, and the corresponding adjusted hazard ratios were 1.40 , 1.31 , and 1.30 . No conversation results for occult metastases were detected. The 5-yr Kaplan-Meier survival estimates for individuals in whom occult metastases were detected had been 94.6 percent for overall survival, 86.4 percent for disease-free survival, and 89.8 percent, 89.2 percent, and 92.5 percent, respectively . Subgroup analysis of outcomes based on the size of occult metastases indicated that smaller sized metastases had less of an effect on outcomes than larger metastases.The secondary hypothesis stated that in such individuals, the addition of tiotropium would not be inferior to the addition of a LABA. We evaluated the principal outcome, the morning hours peak expiratory movement , as well as additional outcomes, in 210 patients with asthma inadequately controlled by a low dosage of an inhaled glucocorticoid. Methods Study Patients In June 2007 Beginning, we enrolled 826 individuals in a common run-in period for two asthma studies. One of the studies, called the very best Adjustment Strategy for Asthma over Long Term trial , involved sufferers with mild-to-moderate disease, and the full total results are not reported here.