The HER2-positive status of most tumors was confirmed with the use of fluorescence in situ hybridization before randomization. In the 1st group, women received standard therapy with doxorubicin and cyclophosphamide every 3 weeks for four cycles, accompanied by docetaxel every 3 weeks for four doses . In the next group, individuals received trastuzumab plus AC-T, beginning with the first dose of docetaxel and ongoing for 1 year . In the 3rd group, patients received docetaxel plus carboplatin , given every 3 weeks for six cycles concurrently with trastuzumab, followed by trastuzumab for yet another 34 weeks .The pimples usually occur on the facial skin, chest, shoulders, neck, or upper part of the relative back. A few of the other medical indications include dark spots with open pores at the guts, which are referred to as blackheads, bulged places under the pores and skin without openings, which are known as whiteheads, and reddish colored swellings or lumps filled up with pus, which are referred to as pustules. The pustules can form from blackheads or whiteheads. Inflamed fluid-filled lumps beneath the skin known as cysts are also an indicator of acne.